2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. HIF/HIF Prolyl-Hydroxylase
  5. HIF/HIF Prolyl-Hydroxylase Antagonist

HIF/HIF Prolyl-Hydroxylase Antagonist

HIF/HIF Prolyl-Hydroxylase Isoform Comparison

HIF/HIF Prolyl-Hydroxylase Antagonists (2):

Cat. No. Product Name Effect Purity
  • HY-108697
    PT2399
    		Antagonist 99.93%
    PT2399 is a potent and selective HIF-2α antagonist, which directly binds to HIF-2α PAS B domain with an IC50 of 6 nM. PT2399 displays potent antitumor activity in vivo.
  • HY-120110
    IOX4
    		Antagonist 99.83%
    IOX4 is a selective HIF prolyl-hydroxylase 2 (PHD2) inhibitor with an IC50 value of 1.6 nM, induces HIFα in cells and in wildtype mice with marked induction in the brain tissue. IOX4 competes with and displaces 2-oxoglutarate (2OG) at the active site of PHD2.